PHARMACEUTICAL COMPOSITION COMPRISING FACTOR VII POLYPEPTIDES AND PAI-1 POLYPEPTIDES Russian patent published in 2007 - IPC A61K38/36 A61K38/57 A61P7/04 

FIELD: medicine, hematology, polypeptides.

SUBSTANCE: invention discloses compositions comprising factor VII or polypeptide relates to factor VII, and PAI-1 or PAI-1-related polypeptide, and for using this composition in treatment of bleeding. Invention discloses a method for treatment of bleeding in a patient, a method for decreasing the coagulation time in a patient, a method for enhancing hemostasis in a patient, a method for increasing the fibrinolysis time in a patient, a method for enhancing clots strength in a subject, a set designated for treatment of bleeding attack. Invention provides the development of compositions that can be used effectively in treatment or prophylaxis of bleeding in blood coagulation disorders, in particularly, the development of compositions as a single, standard medicinal formulation that can be used effectively in treatment or prophylaxis of bleeding or as a procoagulant, the development of compositions, methods for treatment and sets using of that promotes to displaying the synergetic effect, the development of compositions, methods for treatment and sets without essential adverse effects, for example, high level of systemic activation of the blood coagulation system.

EFFECT: improved and valuable medicinal properties of polypeptides and pharmaceutical composition.

53 cl, 4 dwg