POLYPEPTIDE OF VII HUMAN COAGULATION FACTOR, PRODUCTION AND APPLICATION Russian patent published in 2008 - IPC C07K14/745 C12N9/64 C12N15/12 A61K38/48

Abstract RU 2325401 C2

FIELD: medicine.

SUBSTANCE: various polypeptide of VII human coagulation factor characterized by high coagulating activity in comparison to natural factor VIIa and not requiring tissue factor induction for development. Structurally new factors VII are amino acid sequence of natural protein containing substitute L305 Val/Tyr/Ile and one or more substitutes including K337 Ala/Gly/Val/Ser//Thr/Asn/Gln/Asp/Glu; V158 Ser/Thr/Asn/Gln/Asp/Glu; E296 Arg/Lys/Val and M298 Lys/Arg/Gln/Asn. Genetic make-up and expression systems for production of described various factor VII by means of recombinant DNA technologies, as well as application of new polypeptides composing pharmaceutical formulations.

EFFECT: compounds are used for bleeding treatment and coagulation system upkeeping.

31 cl, 1 dwg, 7 ex

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RU 2 325 401 C2

Authors

Persson Ehgon

Olsen Ole Vilsted

Dates

2008-05-27—Published

2002-09-26—Filed