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(19)

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2 307 827

(13)

(51)

IPC

C07C211/63(2006-01-01)

C07C209/40(2006-01-01)

C07C211/19(2006-01-01)

(21) (22)

Application

2006114255/04, 2006-04-27

(24)

Start date

2006-04-27

(22)

Actual filing date

2006-04-27

(45)

Published

2007-10-10

(72)

Inventor

Tandura Stanislav NikolaevichSheludjakov Viktor DmitrievichLebedeva Alla BorisovnaLebedev Anatolij Viktorovich

(73)

Holder

Federal'Noe Gosudarstvennoe Unitarnoe Predprijatie Ordena Trudovogo Krasnogo Znameni Nauchno-Issledovatel'Skij Institut Khimii I Tekhnologii Ehlementoorganicheskikh Soedinenij" Gniikhtehos)

METHOD FOR PRODUCTION OF 2-(1-AMINOETHYL)BICYCLO[2.2.1]HEPTANE HYDROCHLORIDE Russian patent published in 2007 - IPC C07C211/63 C07C209/40 C07C211/19

Abstract RU 2307827 C9

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: invention relates to improved method for production of 2-(1-aminoethyl)bicyclo[2.2.1]heptane hydrochloride useful as active ingredient in drug with high activity against A and B type influenza viruses as well as parainfluenza viruses. Claimed method includes interaction of 5-acetylbicyclo[2.2.1]hept-2-ene with hydroxylamine hydrochloride and sodium hydroxide in aqueous medium followed by hydration of obtained 5-acetylbicyclo[2.2.1]hept-2-ene oxime with hydrogen in presence of Raney nickel and treatment of obtained 2-(1-aminoethyl)bicyclo[2.2.1]heptane with hydrogen chloride or hydrochloric acid, wherein 5-acetylbicyclo[2.2.1]hept-2-ene oxime is hydrated in presence of alkali metal hydroxide or earth-alkali metal oxide or ammonia in lower saturated alcohols at 10-40°C and initial hydrogen pressure of 4.55-5.07 MPa.

EFFECT: Improved method for production of 2-(1-aminoethyl)bicyclo[2.2.1]heptane hydrochloride.

1 cl, 4 ex

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RU 2 307 827 C9

Authors

Tandura Stanislav Nikolaevich

Sheludjakov Viktor Dmitrievich

Lebedeva Alla Borisovna

Lebedev Anatolij Viktorovich

Dates

2007-10-10—Published

2006-04-27—Filed