FIELD: medicine, pharmacology, phytotherapy.
SUBSTANCE: invention proposes two variants of agent possessing angiotropic effect. By the first variant agent comprises selenophospholipocoumarinoprotein representing two polypeptide A- and B-chains. The first chain consists of 20 amino acids and the second chain comprises residues of 29 amino acids joined by disulfide bridge by cysteine residues, and wherein selenium forms bonds between amino acids valine and leucine, between glutamic acids, and two diselenide bonds between A- and B-chain. Coumarins prepared by extraction from legumes, cereals and buckwheat plants are added to carboxyl groups of by-side acids - to residues of glutamic and/or aspartic acids, and/or to C-terminal carboxyl groups and wherein the molar ratio protein : phospholipid : selenium : coumarin = 1:1:8:4, respectively. By the second variant agent comprises selenophospholipocoumarinoprotein wherein flavonoids prepared by extraction of field horse-tail and knot-grass is added to carboxyl groups of by-side chains and/or terminal carbon atom and wherein the molar ratio protein : phospholipid : selenium : coumarin : flavonoids = 1:1:8:4:5, respectively. By the third variant agent comprises selenophospholipocumarinoprotein and calcium cations (Ca2+) and wherein the molar ratio protein : phospholipid : selenium : coumarin : Ca2+ : H2SiO4 2- = 1:1:8:4:8:4, respectively. Invention provides absence of adverse effect on body and promotes to activation of endothelial cells.
EFFECT: valuable biological and medicinal properties of agent.
3 cl, 3 ex
