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2 316 551

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IPC

C07D331/04(2006-01-01)

C07D409/14(2006-01-01)

C07D473/06(2006-01-01)

A61K31/522(2006-01-01)

A61K31/38(2006-01-01)

A61P7/02(2006-01-01)

(21) (22)

Application

2006147423/04, 2006-12-26

(24)

Start date

2006-12-26

(22)

Actual filing date

2006-12-26

(45)

Published

2008-02-10

(72)

Inventor

Khaliullin Ferkat Adel'ZjanovichFilipenko Julija ViktorovnaSaitgalina Ajgul' ZakirovnaSpasov Aleksandr AlekseevichNaumenko Ljudmila Vladimirovna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju" Vpo Bgmu Roszdrava)

DERIVATIVES OF 3-METHYL-7-(THETANYL-3)-XANTHINE POSSESSING HEMORHEOLOGICAL ACTIVITY Russian patent published in 2008 - IPC C07D331/04 C07D409/14 C07D473/06 A61K31/522 A61K31/38 A61P7/02

Abstract RU 2316551 C1

FIELD: organic chemistry, pharmaceutical chemistry, pharmacology, medicine.

SUBSTANCE: invention relates to novel derivatives of 3-methyl-7-(thietanyl-3)-xanthine of formulae (Ia, b, c, d): wherein R means C₂H₅, R₁ means , n = 1 (Ia); R means n-C₃H₇, R₁ means Br, n = 1 (Ib); R means hydrogen atom (H), R₁ means -SCH₂CONHNH₂, n = 0 (Ic); R means H, R₁ means -SCH₂CONHNH₂, n = 2 (Id). Proposed compounds possess the greater hemorheological activity as compared with that of pentoxyphylline and lower toxicity. Invention provides synthesis of novel and not described previously derivatives of 3-methyl-7-(thietanyl-3)-xanthine of formulae (Ia, b, c, d) possessing hemorheological activity.

EFFECT: improved method of synthesis, valuable medicinal property of compounds.

2 tbl, 4 ex

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RU 2 316 551 C1

Authors

Khaliullin Ferkat Adel'Zjanovich

Filipenko Julija Viktorovna

Saitgalina Ajgul' Zakirovna

Spasov Aleksandr Alekseevich

Naumenko Ljudmila Vladimirovna

Dates

2008-02-10—Published

2006-12-26—Filed