FIELD: medicine, pharmacy.
SUBSTANCE: invention describes medicinal formulations and methods for providing the increasing rate of release of paliperidone. The medicinal formulations of sustained release provide the therapeutically effective mean and stable state of the paliperidone concentrations in plasma in a single administration per a day. This dosing regimen as a single dose per a day results to a single plasma paliperidone concentration peak for each 24 h period. Except for, the paliperidone plasma concentration occurs at later period after administration of dose and shows less value as compared the paliperidone plasma concentration that is achieved after administration of paliperidone in medicinal formulation with immediate release.
EFFECT: improved and valuable properties of formulations.
20 cl, 9 dwg, 2 ex
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