DRUG DELIVERY COMPOSITION Russian patent published in 2016 - IPC A61K9/50 A61K47/30 A61K47/02

Abstract RU 2589823 C2

FIELD: pharmaceutics.

SUBSTANCE: group of inventions refers to chemical-pharmaceutical industry. Described two types of vast assemblies compositions for delivery of poorly soluble in medium of gastrointestinal tract drugs. In first version, said composition consists of granules, which comprise: solubility surface-active agent, located around inert substrate; semipermeable coating; medicinal agent particles having effective average size of approximately 2 mqm, located between layer of surface active agent and semi-permeable coating; surface stabiliser adsorbed on surface of drug. Second version of above composition can contain: kernel; surface stabiliser adsorbed on surface of medicinal agent with particle size of approximately 2 mqm; semipermeable coating; solubility agent in form of layer of pH-changing agent, located between layer of medicinal agent and semi-permeable coating.

EFFECT: invention is aimed at improvement of delivery of poorly soluble medicinal agents, having low solubility in medium of gastrointestinal tract.

12 cl, 7 dwg, 7 tbl, 7 ex

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RU 2 589 823 C2

Authors

Raddi Stefen B.

Makgurk Sajmon L.

Patel Rakesh

Bullok Dzhon

Kevalramani Radzh

Dates

2016-07-10—Published

2010-04-08—Filed