FIELD: medicine, oncology, organic chemistry, antibiotics.
SUBSTANCE: invention proposes a combination and corresponding method for treatment of tumors that are positive with respect hormone receptors. Combination comprises rapamycin or 40-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin, or ABT578, or compound of the formula (1): 
or an aromatase inhibitor: atamestan, exemestan, formestan, aminoglutetinide, rogletimide, pyridoglutemife, trilostan, testolactone, ketocona-zol, vorozol, fandrozol, anastrozol or letrozol. In the formula (1) R1 means -CH3 or (C3-C6)-alkynyl; R2 means hydrogen atom (H) or -CH3-CH3-OH; X means oxygen atom (O), (H, H) or (H, -OH) under condition that R2 doesn't mean H if X means O, and R1 means -CH3. Proposed composition shows synergism in suppression of breast cancer proliferation.
EFFECT: valuable medicinal properties of combination.
14 cl
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