1-PHENYL-2-HETEROARYLSUBSTITUTED DERIVATIVES OF BENZIMIDAZOL, THEIR APPLICATION FOR PRODUCTION OF MEDICINAL PRODUCTS, AND PHARMACEUTICALS CONTAINING THESE DERIVATIVES Russian patent published in 2008 - IPC C07D401/04 C07D409/04 C07D413/14 C07D417/14 A61K31/4164 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to new derivatives of benzimidazol of the general formula I R¹ designates phenyl group which unessentially contains up to three substitutors independently chosen of the group including F, Cl, Br, J, R⁴; R² designates monocyclic or bicyclic 5-10-terms heteroaryl group which contains 1-2 heteroatoms, chosen of N, S and O; R³ designates H; R⁴ designates_{C1-6alkyl; A designates C2-6 alkylene group; B designates group COOH, CONH2, CONHR⁵ or CONR⁵R⁵, in each case attached to atom of carbon of group A; R5 and R5 ' independently designate the residue chosen from group includingC1-6 alkyl where one C-atom can be replaced by O, and(C0-3 alkandiil-C3-7 cycloalkyl); and to their pharmaceutically acceptable salts, except for following compounds: 6 [[1-phenyl-2 (pyridine-4-il)-1H-benzimidazol-6-il] oxi] hexanic acid and 6 [[1-phenyl-2 (benzothien-2-il)-1H-benzimidazol-6-il] oxi] hexanic acid. The invention relates also to pharmaceuticals and to application of compounds of general formula I.}

EFFECT: new biologically active compounds possess inhibiting effect on activation of microglia.

10 cl, 34 ex