BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, OBTAINING THEM AND THEIR USE Russian patent published in 2008 - IPC C07D235/08 C07D401/06 C07D405/06 A61K31/4184 A61P25/00 

FIELD: chemistry.

SUBSTANCE: description is given benzimidazole derivatives with general formula I , where Z is chosen from O=; R¹ is chosen from C_1-10alkyl, R⁵ R⁶ N-C_1-6alkyl, R⁵O-C_1-6alkyl, R⁵C(=O)N(-R⁶)-C_1-6alkyl, C_3-10cycloalkyl-C_1-6alkyl, C_3-6heterocycloalkyl-C_1-6alkyl C_3-6heterocyclyl-C(=O)-C_1-6alkyl, C_1-10hydrocarbylamino, R⁵R⁶N-, R⁵O-, R⁵C(=O)N(-R⁶)-, R⁵R⁶NC(=O)N(-R⁷)-, C₃-₁₀cycloalkyl, C₃-₆heterocyclyl and C_3-6heterocyclyl-C(=O)-; R² is chosen from a group consisting of C_1-6alkyl, C_3-8cycloalkyl, C_3-8cycloalkyl-C_1-6 alkyl, C_3-6heterocycloalkyl-C_1-6alkyl, R⁵R⁶N- and C_3-6heterocycloalkyl; R³ and R⁴ are independently chosen from -H, -OH, R and -0-R , where R³ and R⁴ simultaneously do not represent -H. The indicated C_1-6alkyl or bivalent C_1-6group in definition of R⁸ are possibly substituted with one or more groups, chosen from halogen, methoxy, ethoxy, hydroxy and -NR⁵R⁶; or R³ and R⁴ together with the nitrogen atom to which they are bonded, form part of a 5- or 6-member ring. The indicated ring is possibly substituted with one or more groups, chosen from methyl, ethyl, halogen, methoxy, ethoxy, hydroxyl and -NR⁵R. Description is given of a method of obtaining an intermediate product, as well as pharmaceutical compositions, containing formula I compounds.

EFFECT: proposed benzimidazoles relate to therapeutic compounds, which are ligands of receptor CB₁ and can be used in making pain killers.

11 cl, 23 ex