DERIVATIVES OF BENZIMIDAZOL, COMPOSITIONS CONTAINING THEM, OBTAINING AND APPLICATION Russian patent published in 2009 - IPC C07D235/08 C07D405/06 A61K31/4184 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention concerns new compounds of formula I or their pharmaceutically acceptable salts: , where R¹ is selected out of C_3-10cycloalkyl-C_1-6alkyl, tetrahydropyranyl-C_1-6alkyl and tetrahydropyranyl, where the C_3-10cycloalkyl-C_1-6alkyl, tetrahydropyranyl -C_1-6alkyl and tetrahydropyranyl used in definition of R¹ are possibly substituted by one or more group selected out of halogen, methyl and ethyl; R² is C_1-10alkyl, where the C_1-10alkyl used in definition of R² is optionally substituted by one or more group selected out of methyl, ethyl; R³ is selected out of -H, C_1-10alkyl, C_2-10alkenyl, pyrrolidinyl, morpholinyl, piperidinyl, pyrrolidinyl-ethyl, morpholinyl-ethyl, piperidinyl-ethyl and , possibly substituted by one or more group selected out of C_1-6alkyl, amino, C_1-6alkoxy; or R³ is 2-aminoethoxy-ethyl or (2-hydroxyethyl)amino-ethyl; each of R⁸ and R⁹ is C_1-10alkyl; and R⁴ is selected out of -H and C_1-10alkyl. Invention also concerns compounds selected out of the group, application of compounds for any of claim points 1-5, pharmaceutical composition, and method of obtaining compounds of the formula I.

EFFECT: obtaining new bioactive compounds with agonistic effect selective in respect of CB₁ receptors.

11 cl, 12 ex