FIELD: chemistry.
SUBSTANCE: invention relates to bioorganic chemistry and concerns N-acyl derivatives of aminoacids of the general formula I 
, where n is 2 or 3, and R is 
, as well as their pharmaceutically acceptable salts and their application as hypolipidemic preparations. Another subject of invention is pharmaceutical composition containing claimed compounds in pharmaceutically effective quantity and method of treatment of lipidosis, atherosclerosis, cardiac and cerebral ischemia, cardiac infarction, stroke.
EFFECT: obtaining aminoacid derivatives with hypolipidemic effect.
8 cl, 28 tbl, 1 dwg, 22 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING N-ACYL DERIVATIVES OF AMINO ACIDS (VERSIONS) | 2008 |
|
RU2378284C2 |
| PHARMACEUTICAL COMPOSITION, CONTAINING N-ACYL DERIVATIVES OF AMINO ACIDS, AND THEIR APPLICATION AS ANTI-ALLERGIC, ANTI-ANAPHYLACTIC AND ANTI-INFLAMMATORY MEDICATIONS | 2008 |
|
RU2406727C2 |
| APPLICATION OF GLUTARIC ACID DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AS ANTIARRHYTHMIC DRUG | 2008 |
|
RU2373934C1 |
| PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, USE AND PHARMACEUTICAL COMPOSITION | 1997 |
|
RU2141483C1 |
| 2-ETHYL-6-METHYL-3-HYDROXYLIRIDINIUMHYDROXYBUTANEDIOAT EXPRESSING ANTI-ISHEMIC, CEREBROPROTECTIVE, NEUROTROPIC AND LIPID-REGULATING ACTIVITY, PHARMACEUTICAL COMPOSITIONS AND MEDICAL PRODUCT | 2008 |
|
RU2377237C1 |
| PHARMACEUTICAL COMBINATION POSSESSING ANTIAGGREGANT AND LIPID-REGULATING ACTIVITIES, PHARMACEUTICAL COMPOSITION | 2010 |
|
RU2461379C2 |
| PHARMACEUTICAL COMPOSITION SHOWING HEPATOPROTECTIVE EFFECT | 1996 |
|
RU2111747C1 |
| PHARMACEUTICAL COMPOSITION FOR HYPERLIPIDEMIA TREATMENT | 2014 |
|
RU2623876C2 |
| PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HYPERLIPIDEMIA | 2017 |
|
RU2683641C2 |
| METHOD OF SYNTHESIS OF GAMMA-L-GLUTAMYLHISTAMINE, USE OF GAMMA-L-GLUTAMYLHISTAMINE, PHARMACEUTICAL COMPOSITION | 1997 |
|
RU2141968C1 |
