PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, USE AND PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: chemistry of peptides, pharmacy. SUBSTANCE: invention relates to peptides of the general formula (I): R₁-CH₂-CH₂-CONH--CH(R₂)CH₂R₃ or their pharmaceutically acceptable salts where R₁ means hydrogen atom or hydrocarbon C₁-C₃-radical substituted with the functional group, for example, amino, amide with C₁-C₅-radical, C₁-C₇-urethane or carboxy-group or hydrocarbon C₁-C₃-radical substituted simultaneously with amino- or carboxy-group; carboxy-group can be esterified and amino-group can be substituted with acyl substituent or carbonic acid ester; R₂ means hydrogen atom or the functional group, for example, carboxyl that can be esterified; R₃ means indole or its methyl and/or hydroxyl derivatives being hydroxyl group can be acylated, alkylated or aralkylated, 5-6-membered saturated and unsaturated cyclic and heterocyclic substituents containing oxygen, sulfur and/or 1-3 nitrogen atoms or their methyl derivatives; if R₁ is NH₂,NH₂-CH₂- and R₂ is H then R₃ does not mean -4-Im, -3-(5-OMe-Ind), -3-(5-OH-Ind); if R₁ means NH₂,NH₂-CH₂- and R₂ means COOH then R₃ does not mean -4-Im and if R₁ means HOOC-CH(NH₂)- and R₂ means H then R₃ does not mean -3-Ind, -3-(5-OH-Ind). Compounds (I) show properties of modulators of cytochrome P-420 system, metabolism of arachidonic acid, adrenal cortex hormones, macrophage activity and an antioxidant, antihypoxic, antiviral, lipid-regulating, antimetastatic, glucose-decreasing, adaptogenic and other kinds of therapeutic effect. Compounds of the formula (I) are synthesized by acylation of amino-group in the compound (II): NH₂-CH-(R₂)-CH₂-R₃ with a carboxyl component: R₁-CH₂-CH₂-COX where X is an activating group. EFFECT: improved method of synthesis, multitherapeutic effects. 23 cl, 32 tbl, 38 ex