Aβ-PEPTIDE ANTIBODIES AND APPLICATION THEREOF Russian patent published in 2008 - IPC C07K16/18 C12N15/13 C12N15/63 C12P21/00 A61K39/395 A61P25/28 

FIELD: medicine; bioengineering.

SUBSTANCE: are offered variants of antibodies, specifically recognizing two regions of peptide β-A4, characterised by amino-acid residual list. The first region of recognised peptide contains amino-acid sequence AEFRHDSGY or fragment thereof, while the second region contains amino-acid sequence VHHQKLVFFAEDVG or fragment thereof. Described are nucleic acid molecules coding molecules of antibodies, offered in invention, vectors and hosts containing specified nucleic acid molecules. Discovered are methods of antibodies production and optimisation, pharmaceutical compositions based on specified antibodies and method of production thereof, as well as antibodies-based set and various applications of antibodies. Invention application provides high-avidity antibodies of peptide β-A4 that can be applied for diagnostics of various peptide β-A4 mediated diseases.

EFFECT: efficient application of compositions.

29 cl, 15 dwg, 10 tbl, 16 ex