METHOD OF COMPLEX TREATMENT OF SOFT TISSUE SARCOMAS Russian patent published in 2009 - IPC A61K31/675 A61K31/196 A61K33/14 A61K35/16 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention concerns medicine, particularly oncology, and can be applied in treatment of soft tissue sarcomas. Method involves blood collection from peripheral vein in amount of 100-150 ml before operation of malignant soft tissue tumour removal. Further the blood is centrifuged, plasma is collected to two bottles in equal amount. 600 mg of cyclopohsphane is added to the first bottle, 40 mg of methotrexate is added to the second bottle, and both bottles with plasma and chemicals are incubated for 30 minutes at 37°C. After tumour removal, removed tumour bed and surrounding tissues are infiltrated with contents of first bottle and then of second bottle. Remaining structural blood elements are mixed with 100 ml of saline solution and reinfused till the end of operation.

EFFECT: prolonged recurrence-free period, prevented toxic side effects; infiltration of tissues surrounding tumour with maximum quantity of anti-tumour drugs due to creation of chemical drug depot in the tissues; possible surgical tumour removal without extremity amputation and disabiling of patients.

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