PRODUCTION METHOD FOR 1-(4-CHLOROPHENYL)-2-CYCLOPROPYLPROPANE-1-ONE AND BY-PRODUCT THEREFOR Russian patent published in 2009 - IPC C07C49/813 C07C49/235 C07C45/68 

Abstract RU 2350597 C1

FIELD: chemistry.

SUBSTANCE: invention refers to production method of 1-(4-chlorophenyl)-2-cyclopropylpropane-1-one being a by-product for making biologically active substances, as well as to production method for 1-(4-chlorophenyl)-2-methyl-3-butene-1-one being a by-product for making 1-(4-chlorophenyl)-2-cyclopropylpropane-1-one. Production method for 1-(4-chlorophenyl)-2-cyclopropylpropane-1-one consists that 4-chlorobenzonitrile reacts with crotyl chloride or bromide and zinc in organic solvent and optionally with aluminium chloride. Hydrolysis of reaction mixture 2M with hydrochloric acid results in separation 1-(4-chlorophenyl)-2-methyl-3-butene-1-one thereafter purified. It reacts dibromomethane, zinc and copper monochloride in organic solvent with catalyst added or in ultrasonic bath. It is followed with separation of end product by common method.

EFFECT: simple and cheaper end production methods.

4 cl, 2 dwg, 9 ex

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RU 2 350 597 C1

Authors

Uskov Aleksandr Mikhajlovich

Kun Fan' Lehj

Nesterova Lilija Mikhajlovna

Jarovenko Sergej Vladislavovich

Sun' Junkhuehj

Dates

2009-03-27Published

2007-08-02Filed