MONOCYCLIC HETEROCYCLES INHIBITING KINASE Russian patent published in 2009 - IPC C07D213/68 C07D213/73 C07D213/74 C07D213/75 C07D239/34 C07D239/46 C07D401/04 C07D401/06 C07D401/12 C07D401/14 C07D417/12 A61K31/44 A61P35/00 

FIELD: chemistry.

SUBSTANCE: there is disclosed compounds of formula II , where each R² independently stands for H, halogen, cyano, NO₂, OR⁵, NR⁶R⁷, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclo, substituted heterocyclo, arylalkyl, substituted arylalkyl, heterocycloalkyl or substituted heterocycloalkyl; B represents O, S, SO or SO₂; each W and X independently represents C or N; n is within 0 to 4 if both W and X represent C, 0 to 3, if either X or W represent N, and 0 to 2 if both X and W represent N; R³, R⁵, R⁶, R⁷ are independently chosen from H, alkyl, substituted alkyl, alkenyl, alkinyl, substituted alkinyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclo, substituted heterocyclo; R⁴ represents optionally substituted 5-6-merous heteroaryl containing nitrogen atom provided (a) if R⁴ stands for pyridyl, R⁴ is not substituted with both hydroxy and methoxy groups; and (b) R⁴ stands for pyrimidinyl, it is n-substituted =O; A is chosen from following compounds of formula: , where D stands for S or O; m is within 0 to 6; R¹⁶, R¹⁷, R¹⁸, R¹⁹, R²⁰, R²¹, R²², R²³, R²⁴, R²⁵, R²⁶ and R²⁷ are independently chosen from H, halogen, NR³⁰R³¹, OR³², CO₂R³³, SO₂R³⁶, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkinyl, substituted alkinyl, -CN, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl or substituted heterocycloalkyl; R²⁸ and R²⁹ are independently chosen from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl or together they form carbocyclic or heterocyclic ring consisting of 3 to 8 atoms; and R³⁰, R³¹, R³², R³³ and R³⁶ are independently chosen from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkinyl, substituted alkinyl, cycloalkyl, substituted cycloalkyl, alkoxycarbonyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclo, substituted heterocyclo, heterocycloalkyl or substituted heterocycloalkyl as pharmaceutical composition for cancer treatment containing compound of formula II.

EFFECT: production of new compounds and based pharmaceutical composition applied for cancer treatment.

18 cl, 147 ex