SPIROHETEROCYCLIC COMPOUNDS AND USE THEREOF AS THERAPEUTIC AGENTS Russian patent published in 2011 - IPC C07D491/22 C07D495/22 A61K31/438 A61K31/407 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a spiroheterocyclic compound of formula (I):

,

where: p equals 1-4; j and k are each independently equal to 0, 1, 2 or 3; Q denotes -O-, denotes a condensed 5-member heteroaryl ring with one S atom or a 6-member heteroaryl ring with one N atom; R¹ denotes C_1-8alkyl; each R² independently denotes H, C_1-8alkyl; each R^3a, R^3b R^3c and R^3d independently denotes H, C_1-8alkyl, or R^3a and R^3b, or R^3b and R^3c, or R^3c and R^3d, together with carbocycle atoms to which they are directly bonded, can form a condensed dioxolyl ring, and the remaining group R^3a, R^3b R^3c or R^3d is as described above; or a pharmaceutically acceptable salt thereof.

EFFECT: compounds can be used to treat sodium channel-mediated diseases or conditions such as pain.

13 cl, 4 dwg, 2 tbl, 9 ex