MEDICINAL COMPOSITION CONTAINING FLUPIRTIN, WITH CONTROLLABLE RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCE Russian patent published in 2009 - IPC A61K31/4425 A61K9/16 A61K9/22 A61K9/32 A61K9/52 A61J3/10 A61P25/04 

FIELD: medicine.

SUBSTANCE: invention concerns the solid medicinal composition, including flupirtin or its physiologically comprehensible salts as biologically active substance. At least, one part of flupirtin exists as preparative ready form with the slowed down liberation of the active component. The preparative ready form contains the pressed forms flupirtin, which are preferably in regular intervals covered by a prolonging component. Form pressing of flupirtin is characterised by the size of particles of 160-800 mcm, in bulk volume less than 5 ml/g and preferably are spherical or close to spherical. The prolonging component provides diffused-controllable flupirtin release and preferably includes polymer or a copolymer from acrylic acid, derivatives of acrylic acid, methyl-acrylic acid and-or derivatives of the methyl-acrylic acid, or their admixtures.

EFFECT: new flupirtin composition provides uniform and long release of active substance during long time, frequency of reception to two times day, more rare implication of side effects and a risk exception of a "dose dumping".

16 cl, 3 dwg, 3 ex