METHOD OF PREDICTING GASTROPATHIES INDUCED BY INTAKE OF NON-STEROID ANTI-INFLAMMATORY PREPARATIONS Russian patent published in 2009 - IPC A61B8/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to gastroenterology, and can be applied in prediction of gastropathies induced by non-steroid anti-inflammatory preparations. In complex clinic-functional criteria are determined: morbid load, age over 50 years, presence of accompanying diseases, reduction of liver ecogenicity in USE; blood fibrinogen lower than 4.0 g/l, increase of activated partial thromboplastin time (APTT) relative to norm, reduction of fibrinolysis time lower than normal, increase of creatinine in blood higher than 85 mcmole/l, level of antibodies (IgG) to Helicobacter pylori by data of immune-enzyme analysis lower than 2.0, blood leptin higher than 50 mg/ml, activity of blood antithrombin III is lower than normal, level of soluble fibrin-monomer complexes (SFMC) is higher than normal, level of aspartataminotransferase (AST) is higher than normal, C-reactive protein is higher than normal. Each criterion is given "+1" if it is present, and "0" if it is absent, and if sum of criteria is from "0 to 2", low degree of gastropathy development is determined, "from 3 to 5" - medium risk degree, and if value of criteria sum is "6 and higher" - high degree of gastropathy development.

EFFECT: defining 3 groups of risk of NAIP-gastropathies allows to improve approach to management and treatment of patients, taking NAIP, by means of rational use of selective COG - 2 inhibitors, constant therapy with proton pump inhibitors, carrying out FGDS of all patients possessing risk factors.

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