COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS Russian patent published in 2009 - IPC C07D277/56 C07D417/14 C07D417/12 A61K31/426 A61K31/427 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invented compounds have inhibitory activity towards protein kinase. In formula 1a m lies between 0 and 1, R₁ is chosen from a group which includes hydrogen, methyl, isopropyl, imidazolylpropyl, piperazinylpropyl, pyridinyl, diethylaminopropyl, hydroxyethyl, pyrimidinyl, morpholinopropyl, phenyl, cyclopropyl, morpholinoethyl, benzyl and morpholino, where any of pyridinyl, imidazolyl, piperazinyl or pyrimidinyl in R₁ are optionally substituted with 1-3 radicals, independently chosen from a group, which includes methyl, methylamine, dimethylaminomethyl, cycloproylamine, hydroxyethylamine, diethylaminopropylamine, pyrrolydinylmethyl, morpholino, morpholinomethyl, piperazinylmethyl and piperazinyl, where any of morpholino and piperazinyl in R₁ are optionally further substituted with a radical, chosen from a group which includes methyl, hydroxyethyl and ethyl, R₂, R₃ and R₅ each represents hydrogen, R₄ represents methyl, L is chosen from a group which includes -NR₅C(O)- and -C(O)NR₅-, R₁₀ represents trifluoromethyl, and R₁₁ is chosen from a group which includes halogen, morpholinomethyl, piperazinyl, optionally substituted with a methyl, ethyl or hydroxyethyl group; piperazinylmethyl, optionally substituted with a methyl or ethyl group, imidazolyl, optionally substituted with methyl, pyrrolidinylmethoxy and piperidinyl, optionally substituted with a hydroxy group.

EFFECT: more effective treatment.

4 cl, 1 tbl, 3 ex