PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF Russian patent published in 2012 - IPC C07D487/04 C07D239/08 C07D213/02 C07D231/56 C07D231/10 C07D215/00 C07D277/38 C07D277/62 C07D333/04 C07C15/24 C07D333/52 C07D265/00 C07D211/00 C07D241/00 C07D233/00 A61K31/40 A61K31/44 A61K31/495 A61K31/41 A61K31/5377 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. In formula (I): X denotes a single bond or a binding group selected from -CO, -SO₂-, -CS- or -CH₂-; Y denotes a single bond or a divalent binding group obtained from a cyclic structure selected from benzene, pyridine, pyrimidine, pyrazole, imidazole, thiazole, thiophene, quinoline, benzoimidazole, benzothiazole, benzopyrazole, naphthalene and benzothiophene; X and Y are simultaneously single bonds; Z denotes a hydrogen atom or a substitute selected from a group A; m equals 1 or 2; n equals 0-3; in group A and group B, R, R' and R" can, respectively and independently, be identical or different and denote a hydrogen atom or -C_1-6-alkyl; said -C_1-6-alkyl can be substituted with a group selected from -OH, -O(C_1-6-alkyl),-CONH₂, -CONH(C_1-6-alkyl), -CON(C_1-6-alkyl)₂, -NH₂, -NH(C_1-6-alkyl) and -N(C_1-6-alkyl)₂); Sus denotes a C₃-C₇ saturated or a C₅-C₁₀ unsaturated hydrocarbon ring or a nitrogen-containing C₃-C₇ heterocyclic ring containing 1-4 nitrogen atoms or containing an additional O, S atom; said C_1-6 alkylene in groups A and B can be substituted in positions 1-3 with a -N(C_1-6- alkyl)₂ group, values of radicals R¹, A¹, T, B and Q are given in the claim. The invention also relates to a pharmaceutical composition containing said compounds, a PI3K inhibitor and a medicinal agent having PI3K inhibitor properties against a proliferative diseases such as a malignant tumour.

EFFECT: high efficiency of using the compounds.

21 cl, 645 ex