DERIVATIVES OF ARYL- AND HETEROARYLPIPERIDINECARBOXYLATES, THEIR PRODUCTION AND THEIR USE AS INHIBITORS OF FAAH FERMENT Russian patent published in 2009 - IPC C07D471/04 C07D401/04 C07D401/06 C07D211/52 C07D211/36 C07D413/04 C07D417/04 A61K31/4523 

FIELD: medicine.

SUBSTANCE: invention is related to new derivatives of aryl and heteroarylpiperidinecarboxylates, of formula (I): , where: type means integer numbers from 1 to 3, such that m+n is integer number from 2 to 5; p means integer number from 1 to 7; A means simple connection or is selected from one or several groups X, Y; X means -CH₂-; Y means C₂-alkynilene group; R₁ means group R₅, substituted with one or several groups R₆ and/or R₇; R₂ means H, F, OH; R₃ means H; R₄ means H, C_1-6-alkyl; R₅ means group selected from phenyl, pyridinyl, pyrimidinyl, pyrrolyl, imidazolyl, thiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, naphthyl, chinolynyl, tetrahydrochinolinyl, isochinolinyl, tetrahydroisochinolinyl, indolyl, indolinyl, isoindolyl, benzimidazolyl, benzoxazolyl, benzizoxazolyl, benzothiazolyl, benzithiazolyl, benzotriazolyl, benzoxadiazolyl, pyrrolopyridinyl; R₆ means halogen, CN, C_1-6-alkyl, C_3-7-cycloalkyl, C_1-6-alkoxy, OH, C_1-6-fluoroalkyl, C_1-6-fluoroalkoxy, or cycle selected from pyrrolidine and piperidine cycle, besides this cycle is unnecessarily substituted with C_1-6-alkyl group; R₇ means phenyl group, besides group or groups R₇ may be substituted with one or several groups R₆, identical or differing from each other, selected from halogen, C_1-6-alkyl and C_1-6-fluoroalkyl, C_1-6-alkoxy, in the form of pharmaceutically acceptable base or acid-additive salt.

EFFECT: compounds are applicable as inhibitors of FAAH ferment.

10 cl, 1 tbl, 7 ex