PRIMARY AMINE DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES Russian patent published in 2016 - IPC C07D207/12 C07D207/273 C07D207/48 C07D211/46 C07D211/96 C07D223/08 C07D309/12 C07D401/04 C07D401/06 C07D401/10 C07D401/14 C07D403/04 C07D403/10 C07D405/12 A61K31/445 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, which have antihypertensive action. In formula I X represents O or NR⁷; group is bonded to any carbon ring atom, different from carbon atom to which are bonded R¹ and R²; R¹ represents hydrogen or together with R² forms =O; R² represents hydrogen or together with R¹ forms =O; R⁴ is -C_1-6alkyl; R⁵ and R⁶, which are bonded to any available carbon ring atom, independently represent hydrogen or R⁵ and R⁶ in cases when they are bonded to same carbon atom, form =O; R⁷ is -C_1-6alkyl, -C(O)O-C-_1-6alkyl, -C(O)O-C-_1-6alkylene-CR⁸R⁹R¹⁰, -C(O)C_1-6alkyl, -C(O)OC_3-6carbocycle, -C(O)aryl, -C(O)heteroaryl, where heteroaryl is unsaturated 5- or 6-member ring containing 1-4 heteroatoms selected from N, -C(O)NHC_1-6alkyl, -C(O)NH-adamantyl, -SO₂C_1-6alkyl, aryl or unsaturated 5- or 6-Member heteroaryl ring containing 1-4 heteroatoms selected from N, where aryl, alkyl, alkylene, carbocycle and heteroaryl are unsubstituted or substituted with 1-4 groups independently selected from -CN, halogen, -CF₃, -OCF₃, -C(O)NH₂, -C-_1-6alkyl, aryl, unsaturated 5-member heteroaryl ring with 1-3 nitrogen atoms, where R⁸ and R⁹ together with carbon atom to which they are bonded form C_3-6carbocycle or 4-8-member heterocycle containing an oxygen atom, and where R¹⁰ is C_1-6alkyl.

EFFECT: invention also relates to pharmaceutical compositions containing said compounds, and a method of treating hypertension.

29 cl, 43 ex