SUBSTITUTED CYCLIC COMPOUND, METHOD OF PREPARING SAID COMPOUND AND MEDICINAL APPLICATION THEREOF Russian patent published in 2010 - IPC C07D213/16 C07D401/08 C07D401/14 A61K31/4412 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to novel substituted cyclic compounds with the following general formula I or II and to pharmaceutically acceptable salts thereof and to all stereo isomers and optical isomers thereof:

, , where n equals 1, X and Y are NH; R₁ and R₂ independently represent one substitute selected from a group consisting of aryl; 2-, 3-, or 4-pyridyl; aryl substituted with one, two or three groups selected from C₁-C₄alkyl, nitro, carboxyl, aldehyde, alkoxy, amino, amido, carbamide, mercapto, methylthio, ethylthio; R₃ and R₄ independently represent one substitute selected from a group consisting of aryl; 2-, 3- or 4-pyridyl; aryl substituted with one, two or three groups selected from C₁-C₄alkyl, nitro, carboxyl, aldehyde, alkoxy, amino, amido, carbamide, mercapto, methylthio, ethylthio; 2-, 3- or 4-pyridyl, substituted with one, two or three groups selected from C₁-C₄alkyl, nitro, carboxyl, aldehyde, alkoxy, amino, amido, carbamide, mercapto, methylthio, ethylthio. The invention also relates to a method of producing a range of substituted cyclic compounds and their salts in any of subclaims 1-4, to a pharmaceutical composition, to use, to a method of treating and preventing diseases as well as to an assembly.

EFFECT: obtaining new biologically active compounds suitable for treating or preventing diseases or symptoms, arising from or accompanied with violation of secretion and/or function of insulin.

13 cl, 4 ex, 3 tbl, 6 dwg