COMBINATIONS WHICH INCLUDE RECEPTOR S1P AGONIST AND JAK3 KINASE INHIBITOR Russian patent published in 2011 - IPC A61K45/06 A61K31/519 A61K31/135 A61P37/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medications and deals with pharmaceutical combination, intended for application in method of treatment and prevention of autoimmune diseases and malfunctions, or transplant rejection, which includes 2-amino-2-[2-(4-octophenyl)ethyl]propane-1,3- diol(FTY720), phosphate or pharmaceutically acceptable salt of claimed compound and kinase inhibitor JAK3, which represents 3{(3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino]pyperidine-1-yl}-3-oxopropyonitrile monocitrate (CP-690555), in efficient quantities. Also described is method of treatment and prevention of autoimmune diseases or cell, tissue or organ transplant rejection with application of claimed combination.

EFFECT: insuring effective and safe agents for treatment or prevention of autoimmune diseases and conditions or transplant rejection.

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