FIELD: medicine, pharmaceutics.
SUBSTANCE: oral controlled-release dosage form includes granules of therapeutically effective amount of pharmacologically high water-soluble active substance, and at least one nonpolymeric release inhibitor. Said granules are combined at least with one pH-independent nonswelling release inhibitor representing a polymer. Nonpolymeric release inhibitor represents glyceryl behenate. Polymeric pH-independent release inhibitor preferentially represents mixed polyvinyl acetate and polyvinyl pyrrolidone (Collidone SR). The active substance preferentially represents vitamin C.
EFFECT: dosage form provides controlled release of an active component with the reduced initial "explosive" release.
34 cl, 4 dwg, 19 tbl, 10 ex
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