FIELD: medicine.
SUBSTANCE: invention belongs to the field of medicine, notably to remedy for arterial hypertension and cardiac dysrhythmia treatment, which includes water-soluble complex of nifedipine (dimethyl ether of 2,6-dimethyl-4-(2ґ-nitrophenyl)-1,4-dihydropiridin-3,5-dicarboxylic acid) with polysaccharide, namely arabinogalactan, obtained as a result of mechanochemical activation of hard components mix with weight ratio nifedipine/arabinogalactan 1:(10-40) in a planetary mill at acceleration 60 g. Complex shows higher antihypertensive activity in tenfold lower dose of nifedipine, and high dysrhythmic activity in two hundredfold lower dose of nifedipine compared with dose, which brings hypotensive effect. Besides complex has higher water solubility.
EFFECT: remedy for arterial hypertension and cardiac dysrhythmia treatment is offered.
1 cl, 2 dwg, 3 tbl, 3 ex
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