DI-3-(3,5-DI-TERT-BUTYL-4-HYDROXYPHNYL)-2-HYDROXY-1-(N ISOPOPYLAMINO)PROPANE SUCCINATE WITH ANTIARRHYTMIC ACTIVITY Russian patent published in 2010 - IPC C07C215/56 C07C215/66 A61K31/14 A61P9/06 A61P9/12 

Abstract RU 2396248 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, specifically to a new compound - di-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-hydroxy-1-(N-isopropylamino)propane succinate with antiarrhythmic and antihypertensive activity. The compound (1) is three-stage synthesised. At the first stage, ethylene chlorohydrin and tin tetrachloride are added to 2,6-di-tert-butylphenol solution in trichloroethylene. The prepared compound is heated with isopropyl amine that leads to formation of related amine. An end-product succinate (1) is prepared by mixing of amine solution and succinic acid in acetone wherein succinate (1) is precipitated as white crystals.

EFFECT: preparation of the compound with antiarrhythmic and antihypertensive activity.

3 ex, 2 tbl

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RU 2 396 248 C1

Authors

Krysin Aleksej Petrovich

Tolstikova Tat'Jana Genrikhovna

Bryzgalov Arkadij Olegovich

Shul'Ts Ehl'Vira Ehduardovna

Shakirov Makhmut Minakhmetovich

Dates

2010-08-10Published

2008-12-03Filed