FIELD: medicine, pharmaceutics.
SUBSTANCE: there are described novel compounds of formula 
(I), where R1 represents hydroxymethyl; R2 is selected from -C(O)NR4R5; HET-1 represents 5- or 6-member heteroaryl ring, bound by atom C; R3 represents halogeno; R4 and R5 together with nitrogen atom, to which they are bound, can form heterocyclyl ring system, as it is defined for HET-3; HET-3 represents possibly substituted azetidinyl; m equals 1; n equals 0, 1 or 2; or their pharmaceutically acceptable salt, which can be applied as glucokinase (GLK) activators or active ingredient of pharmaceutical compositions, also described are methods of obtaining them.
EFFECT: creation of novel compounds applied as glucokinase (GLK) activators in treatment of diabetes.
13 cl, 40 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BENZAMIDE DERIVATIVES AND APPLICATION AS GLUCOKINASE ACTIVATION AGENTS | 2005 |
|
RU2392275C2 |
| BENZOYLAMINOHETEROCYCLYL COUMPOUNDS AS GLUCOKINASE (GLK) ACTIVATORS | 2007 |
|
RU2440992C2 |
| DERIVATIVES OF PYRIMIDINE SULFONAMIDE AS MODULATORS OF CHEMOKINE RECEPTORS | 2005 |
|
RU2408587C2 |
| NOVEL PHENYL PYRROLE DERIVATIVE | 2009 |
|
RU2470917C2 |
| HETEROARYLBENZAMIDE DERIVATIVES APPLIED AS GLK ACTIVATORS IN DIABETES TREATMENT | 2006 |
|
RU2415141C2 |
| DERIVATIVES OF 1'-(2-HYDROXY-3-ARYLOXYPROPYL-1-YL)-SUBSTITUTED SPIRO[BENZOFURAN-PIPERIDINES], SPIRO[BENZOFURAN-PYRROLIDINES] AND SPIRO[CHROMEN-PIPERIDINES], METHOD FOR THEIR PREPARING, INTERMEDIATE COMPOUND AND METHOD FOR ITS PREPARING, PHARMACEUTICAL COMPOSITION, USING | 2003 |
|
RU2320664C2 |
| 3-AMINOPYRROLIDINE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | 2003 |
|
RU2355679C2 |
| AMIDE DERIVATIVES | 2004 |
|
RU2375352C2 |
| PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | 2013 |
|
RU2658006C2 |
| CHEMICAL COMPOSITIONS, FORMULATIONS AND METHODS OF THEIR APPLICATION | 2005 |
|
RU2413720C2 |
