METHOD FOR SYNTHESIS OF N-SUBSTITUTED SALICYLAMIDES Russian patent published in 2010 - IPC C07C235/60 C07C231/08 C07C233/24 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of synthesis of N-substiuted salicylamide, involving reaction of a carsalam derivative with a chloro-substituted compound of formula (III) in the presence of a catalytic amount of a source of bromine ions, where n is an integer from 1 to 8, Q denotes a protected carboxylic group, and R⁵ and R⁶ are independently selected from a group containing hydrogen, -OH, NR³R⁴, halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₂-C₄ alkenyl, where R³ and R⁴ are each independently selected from a group containing hydrogen, -OH, C₁-C₄ alkyl, C₁-C₄ halogenalkyl, C₁-C₄ alkoxy and C₂-C₄ alkenyl. The invention also discloses a method for synthesis of a compound of general formula IV.

EFFECT: improved method for synthesis of N-substituted salicylamide enables to obtain large amounts of high-quality product.

54 cl, 3 ex