METHOD OF PRODUCING ASSOCIATED VACCINE AGAINST STREPTOCOCCOSIS AND STAPHYLOCOCCOSIS OF CATTLE Russian patent published in 2010 - IPC A61K39/116 A61K39/09 A61K39/85 

FIELD: medicine, veterinary.

SUBSTANCE: invention relates to field of veterinary medicine. Method lies in the following: carried out is selection of affected organs of dead cattle from local epizootic centre, from which suspension is prepared. After that, performed is inoculation on differential-diagnostic media and pure cultures are separated, and causative agents of streptococcosis Streptococcus bovis and staphylococcosis Staphylococcus aureus are grown separately in meat-peptone broth with addition of glucose to 0.2% concentration with titre 4-5 billion in 1 cm³. Cultures are inactivated by introduction of formalin to 0.4-0.5% final concentration and kept at temperature 37°C for 72-96 hours. After that, cultures are mixed in equal ratios, solution of aluminium hydroxide is introduced in amount 20% to the volume, thoroughly mixed and packed.

EFFECT: method is simple in application and allows to produce safe, specific, highly immunogenic vaccine.

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