PREPARATION FOR TRANSDERMAL NICOTINE INTRODUCTION AND METHOD FOR MAKING THEREOF Russian patent published in 2010 - IPC A61K9/70 A61F13/02 A61K31/465 A61P25/26 

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, more specifically to a method for making a preparation for transdermal nicotine introduction that enables to produce said preparation for transdermal nicotine introduction by convenient and economical way with maintaining high-precision equal nicotine concentration, that enables to produce the preparation being fixedly and softly attached due to reduced skin irritation after removal and excellent adhesiveness. The present invention refers to the preparation for transdermal nicotine introduction characterised by excellent equal nicotine concentration with fixed and soft attachment and reduced skin irritation after removal. There is described the method for making the preparation containing a substrate and a formed adhesive layer which contains nicotine and an adhesive-compatible liquid ingredient; where the method involves: (1) preparing the adhesive layer in which a nicotine wetting angle of the adhesive layer before nicotine coating makes 20-60°, and (2) coating the adhesive layer with nicotine to ensure nicotine absorption in the adhesive layer; as well as to the preparation containing the substrate and the formed adhesive layer containing nicotine and the adhesive-compatible liquid ingredient in which the nicotine wetting angle of the adhesive layer before nicotine coating makes 20-60°.

EFFECT: development of an advantageous process of the preparation for transdermal nicotine introduction.

6 cl, 7 tbl, 14 ex, 4 dwg