CONDENSED TRICYCLIC DERIVATIVES FOR TREATING PSYCHOTIC DISORDERS Russian patent published in 2011 - IPC C07D498/04 C07D471/04 A61K31/4738 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula pharmaceutically acceptable salts thereof, where ---- independently denotes a single or double bond; ring Q is imidazole, triazole (for example 1,2,3-triazole or 1,3,4-triazole), tetrazole or oxadiazole; B denotes C(R⁷)(R⁸) or C(R⁷), where if the bond between B and Y is a single bond, B denotes C(R⁷)(R⁸), and when the bond between B and Y is a double bond, B denotes C(R⁷); Y denotes C(R⁷), C(R⁷)(R⁸) or O, where if the bond between B and Y is a single bond, Y denotes C(R⁷)(R⁸) or O, and when the bond between B and Y is a double bond, B denotes C(R⁷); Z¹ denotes -CH₂-, -(CH₂)₂-, -CH₂CH-CH₃-, where Z¹ is bonded on the left side to a nitrogen atom or -(CH₂)₃-; X denotes C(R¹) or N; A denotes quinolyl, quinazolinyl or benzofuranyl, any of which is optionally substituted with 1-4 substitutes, which can be identical or different and are selected from a group comprising halogen, cyano, C_1-6-alkyl, halogen-C_1-6-alkyl, C(O)N(R³)(R⁴), 5-member heterocyclic ring containing 1-3 heteroatoms selected from N or O. The heterocyclic ring is optionally substituted with C_1-6-alkyl; when R is present, each independently denotes halogen, C_1-6-alkyl; each R¹ denotes hydrogen or methyl; each R² denotes cyano, C_1-6-alkyl, C_1-6-alkoxy, halogen-C_1-6-alkyl, =O, -C(O)N(R³)(R⁴), -C(O)N(R³)-C_1-6-alkoxy, -C(NOR⁵)R⁶, -C(O)R⁶, -C(O)OR⁷, -C(O)NHNHC(O)R⁶, 5-member heterocyclic ring containing 1-3 heteroatoms selected from N or O. The heterocyclic ring is optionally substituted with C_1-6-alkyl; R³ and R⁴ independently denote hydrogen; C_1-6-alkyl; C_3-7-cycloalkyl; C_3-7-cycloalkyl-C_1-6-alkyl; or when R³ and R⁴ are bonded to the same nitrogen atom, they, together with the nitrogen atom, they form a 4-, 5- or 6-member ring which optionally contains one extra O atom in the ring; R⁵ denotes C_1-4-alkyl; R⁶ denotes C_3-7-cycloalkyl or C_1-6-alkyl; R⁷ and R⁸ independently denote hydrogen or C_1-6-alkyl; p equals 0, 1 or 2; r equals 0, 1, 2 or 3; s equals 0, 1, 2 or 3. The invention also relates to 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazin-3-carboxamide, 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperidinyl]ethyl}imidazo-[1,5-a]quinoline-3-carboxamide, dihydrochloride 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperidinyl]ethyl}[1,2,3]triazolo[1,5-a]quinoline-3-carboxamide, 7-methyl-6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4,5-dihydroimidazo[1,5-a]quinoline-3-carboxamide, to use of the compound in any of claims 1-16, as well as a pharmaceutical composition.

EFFECT: obtaining novel biologically active compounds, having 5-HT₁ receptor mediated activity.

23 cl, 195 ex