1-ALKYL-2-ALKYLCARBAMOYL-GLYCERINS EXHIBITING ANTIHYPERTENSIVE ACTIVITY, AND METHOD FOR PREPARING THEREOF Russian patent published in 2011 - IPC C07C271/12 C07C269/02 A61P9/12 A61K31/27 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, namely to an agent exhibiting antihypertensive activity which represents 1-alkyl-2-alkylcarbamoylglycerins of general formula I . In formula I R means hydrocarbon radical -(CH₂)_nCH₃ (n=10-18), R¹ means methyl or ethyl. Also, the invention refers to a method for preparing the compounds of formula I. The method consists in the fact that parent 1-alkylglycerins of general formula II react with trimethylchlorosilane with using triethylamine in toluene medium at temperature -20°C to 0°C, then the reaction mass is added with appropriate alkylisocyanate and processed with ammonium bifluoride in methanol medium at room temperature.

EFFECT: preparation of the agent exhibiting antihypertensive activity.

2 cl, 7 ex