FIELD: medicine.
SUBSTANCE: invention refers to aryl-izoxazole-4-yl-imidazo[1,5-a]pyridine derivatives of formula I and to their pharmaceutically acceptable acid addition salts. In formula I 
, R1 represents hydrogen atom; R2 represents hydrogen atom; R3 represents hydrogen atom, cyano or -(CO)-Ra; Ra represents lower alkoxy or NR'R" where each of R' and R" independently represents hydrogen atom, 6-members heterocycloalkyl with the 1st heteroatom selected from O, or lower alkyl substituted by C3-C7-cycloalkyl. The invention also refers to a drug exhibiting affinity and selectivity to GABA(A) α5-receptor binding sites, containing one or more compounds of formula I and to an application of the compound of the invention in producing the drug exhibiting affinity and selectivity to GABA(A) α5-receptor binding sites.
EFFECT: improved efficacy of the drug.
7 cl, 2 dwg, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ARYL-ISOXAZOL-4-YL-IMIDAZO[1,2-a]PYRIDINE SUITABLE FOR TREATING ALZHEIMER'S DISEASE THROUGH GABA RECEPTORS | 2007 |
|
RU2426732C2 |
| IMIDAZO[1,5-a]PYRIMIDO[5,4-d][1]BENZAZEPINE DERIVATIVES AS MODULATORS OF GABA A RECEPTOR | 2002 |
|
RU2287531C2 |
| TRIAZOLE DERIVATIVES AS GABA RECEPTOR LIGANDS | 2011 |
|
RU2582337C2 |
| APPLICATION OF ACTIVE PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES | 2011 |
|
RU2563167C2 |
| ARYL-ISOXAZOLE-4-YL-IMIDAZOLE DERIVATIVES | 2006 |
|
RU2425045C2 |
| DERIVATIVES OF BENZODIAZEPINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2001 |
|
RU2278865C2 |
| DERIVATIVES OF N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDES AND THEREOF APPLICATION AS PDE10A INHIBITORS | 2011 |
|
RU2562066C2 |
| TRIAZOLE DERIVATIVES AND APPLICATION THEREOF IN NEUROLOGICAL DISEASES | 2011 |
|
RU2581504C2 |
| THIAZOLO[4,5-c]PYRIDINE DERIVATIVES mGluR5 RECEPTOR ANTAGONISTS | 2006 |
|
RU2425834C2 |
| ARYL-ISOXAZOL-4-YL-OXADIAZOLE DERIVATIVES | 2006 |
|
RU2426731C2 |
