IMIDAZO[1,5-a]PYRIMIDO[5,4-d][1]BENZAZEPINE DERIVATIVES AS MODULATORS OF GABA A RECEPTOR Russian patent published in 2006 - IPC C07D487/14 A61K31/55 A61P25/28

Abstract RU 2287531 C2

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to derivatives of imidazo[1,5-a]pyrimido[5,4-d][1]benzazepine of the formula (I): , wherein R¹ means halogen atom or (lower)alkyl; R² means hydrogen atom, (lower)alkyl, (C₃-C₇)-cycloalkyl, -(CH₂)_m-phenyl wherein phenyl ring can be substituted with (lower)alkoxy-group or it means -(CH₂)_m-indolyl; R³ means -C(O)O-(lower)alkyl, -C(O)OH or five-membered heteroaromatic group comprising nitrogen and oxygen atoms as heteroatoms and wherein rings can be substituted with (lower)alkyl or (C₃-C₇)-cycloalkyl; n means 0, 1 or 2; m means 0, 1 or 2, and their pharmaceutically acceptable acid-additive salts. Compounds of this class elicit the high degree and selectivity to binding sites of GABA A α5-receptor and can be used in treatment of the conception enhancer or disorders of cognitive ability similar with Alzheimer's disease.

EFFECT: valuable medicinal properties of derivatives.

10 cl, 6 sch, 41 ex

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RU 2 287 531 C2

Authors

Mashiadri Raffaehllo

Tomas Ehndr'Ju Uill'Jam

Vikhmann Jurgen

Dates

2006-11-20—Published

2002-05-08—Filed