FIELD: chemistry.
SUBSTANCE: invention relates to methods for chemoselective pegylation of a cysteine residue, having an unoxidised sulfhydryl side chain and a free α-amino group in peptides.
EFFECT: disclosed are similar methods for chemoselective pegylation of homo-cysteine, selenocysteine, penicillamine and N-methylcysteine residues.
13 cl, 19 ex
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