FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of biotechnology. Claimed is composition of buffer of pharmaceutical composition which contains pertuzumab. Hystidine-acetate- based buffer which has pH level from 5.5 to 6.5.
EFFECT: reduction of deamination and aggregation of pertuzumab in process of long-term storage.
44 cl, 12 ex, 9 tbl, 33 dwg
Title | Year | Author | Number |
---|---|---|---|
COMPOSITION CONTAINING ANTIBODY BINDING TO DOMAIN II OF HER2, AND ITS ACIDIC VERSIONS | 2009 |
|
RU2543664C2 |
COMPOSITION OF HER2 ANTIBODIES | 2005 |
|
RU2361880C2 |
INTRODUCTION OF FIXED DOSES OF HER-ANTIBODIES | 2005 |
|
RU2438705C2 |
THERAPY OF MALIGNANT TUMOR, RESISTANT TO PLATINUM-BASED MEDICATIONS | 2005 |
|
RU2403065C2 |
ANTI-HER2 ANTIBODY DRUGS FOR SUBCUTANEOUS INJECTION | 2018 |
|
RU2750821C2 |
ALLOSTERIC ANTIBODIES AGAINST HUMAN HER3 NON COMPETITIVE FOR NEUREGULIN AND USE THEREOF | 2013 |
|
RU2704228C2 |
VERSIONS OF PERTUZUMAB AND THEIR ANALYTICAL CHARACTERISTICS | 2014 |
|
RU2737727C2 |
BINDING POLYPEPTIDES AND USE THEREOF | 2006 |
|
RU2470941C2 |
TRISPECIFIC BINDING MOLECULES, WHICH SPECIFICALLY BIND ANTIGENS OF A VARIETY OF MALIGNANT TUMORS, AND METHODS OF USING THEM | 2015 |
|
RU2718692C2 |
BISPECIFIC BINDING MOLECULES CAPABLE OF BINDING CD137 AND TUMOR ANTIGENS AND VARIANTS OF THEIR APPLICATION | 2018 |
|
RU2805648C2 |
Authors
Dates
2011-08-20—Published
2005-10-19—Filed