BISPECIFIC BINDING MOLECULES CAPABLE OF BINDING CD137 AND TUMOR ANTIGENS AND VARIANTS OF THEIR APPLICATION Russian patent published in 2023 - IPC C07K16/30 C07K16/40 A61K39/395 A61P35/00 

Abstract RU 2805648 C2

FIELD: biotechnology.

SUBSTANCE: novel HER2/neu-binding molecule has been proposed. A pharmaceutical composition containing said binding molecules and the use of said molecules for the treatment of diseases and conditions associated with HER2/Neu expression, such as cancer, are also proposed.

EFFECT: obtaining binding molecules with improved binding affinity for HER2 and improved stability.

12 cl, 81 dwg, 15 tbl, 11 ex

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RU 2 805 648 C2

Authors

Lyu, Litsin

Lam, Chia-In Kao

Didrikh, Gundo

Dzhonson, Lesli S.

Mur, Pol A.

Bonvini, Etsio

Dates

2023-10-23Published

2018-02-22Filed