METHOD OF PRODUCING 2-METHYL-4-HALOGEN-PHENOXYACETATES OF TRIS-(2-HYDROXYETHYL)AMMONIUM (2-METHYL-4-HALOGEN-PHENOXYACETOXYPROTATRANES) Russian patent published in 2011 - IPC C07C215/40 C07C59/70 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing biologically active pluripotential compounds - 2-methyl-4-halogen-phenoxyacetates of tris-(2-hydroxyethyl)-ammonium of general formula given below referred to as chlorocresacin and bromocresacin respectively, by reacting 4-halogen-substituted 2-methyl-phenoxyacetic acid, where the halogen is chlorine or bromine, with triethanolamine. 4-halogen-substituted 2-methyl-phenoxyacetic acid is obtained via chlorination with sulphuryl chloride, where catalyst used is aluminium powder in an ester solution and bromation is carried out using elementary bromine in a glacial acetic acid medium. The obtained compounds have proven to be highly efficient biologically active substances with unique physiological action, for example as biostimulators or adaptogen. The method is characterised by replacement of chlorine gas with sulphuryl chloride which is more suitable for use in preparations. .

EFFECT: method enables to obtain desired products with high degree of purity.

2 cl, 5 ex