BLEACHING AGENT AND COMPOSITION FOR SKIN FOR EXTERNAL APPLICATION Russian patent published in 2011 - IPC A61K31/506 A61K8/49 A61Q19/02 A61P17/16 C07D403/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to agent for skin bleaching, representing pyrimidyl pyrazole compound of formula (1), where R₁, R₃, R₄ and R₆ each independently represents C_1-3alkyl and R₂ and R₅ each independently represents hydrogen atom or C_1-3alkyl, or its pharmacologically acceptable salt. Said agent inhibits production of melanin, possesses low cytotoxicity and can be used as bleaching agent for improvement or prevention of pigment spots, freckles, skin darkening, etc. Invention also relates to composition for skin bleaching for external application, which contains effective amount of said pyrimidyl pyrazole compound of formula (1), described in any of items 1-3, or its pharmacologically acceptable salt. Preferable composition represents cosmetic preparation.

EFFECT: obtaining agent for skin bleaching.

6 cl, 3 tbl, 17 ex