COFORMULATED DRUGS CONTAINING 2-ETHYL-3-(N,N-DIMETHYLCARBAMOYLOXY)-6-METHYLPYRIDINE SALTS WITH ORGANIC AND INORGANIC ACIDS AND SUCCINIC ACID SHOWING ANTIHYPOXIC, ANTIAMNESTIC AND ANTICONVULSANT ACTIVITY Russian patent published in 2012 - IPC A61K31/4412 A61K31/194 A61P9/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: what is offered is a coformulated drug for treating various ischemic pathologies containing succinic acid and 2-ethyl-3-(N,N-dimethylcarbamoyloxy)-6-methylpyridine salts with succinic or hydrochloric acid of general formula I where HX is salt-forming succinic or hydrochloric acid, m + 0.1-3.0; showing antihypoxic, antiamnestic and anticonvulsant activity characterised by the fact the relation in I between 2-ethyl-3-(N,N-dimethylcarbamoyloxy)-6-methylpyridine salts and the second component providing a 'synergistic' (potentiating) pharmacological effect by succinic acid makes 1:>0.3. It is shown that succinic acid potentiates declared action of the compound of formula I. It is a reason to create the coformulated drugs exceeding common preparations of 3-oxypyridine groups in pharmacological activity: emoxypin and mexidol, used for treating ischemic pathologies, particularly in diseases accompanied by cerebral ischemia.

EFFECT: preparation of new pharmaceutical compositions for treating ischemic pathologies.

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