FIELD: pharmaceutical chemistry.
SUBSTANCE: invention refers to the field of pharmaceutical chemistry, and more precisely to a new way of buserelin production with the formula: pGlu-His-Trp-Ser-Tyr-D-Ser(Bu1)-Leu-Arg-Pro-NH-C2H5·2AcOH (I) consisting in the fact that the synthesis is performed by means of condensing of C-ended protected dipeptide with the formula: X-pGlu-His-OH (IIa), where X is a protective group, with N-ended protected heptapeptide with the formula: H-Trp-Ser-Tyr-D-Ser(Bu1)-Leu-Arg-Pro-NH-C2H5 (III) and obtained N-protected nonapeptide ethylamide with the formula: X-pGlu-His-Trp-Ser-Tyr-D-Ser(Bu1)-Leu-Arg-Pro-NH-C2H5 (IV) that is treated with an unblocking agent in order to remove the N-protective group, and the end product is extracted with the help of chromatography.
EFFECT: way of buserelin production.
4 cl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR SYNTHESIS NONAPEPTIDE ETHYLAMIDE AND INTEMEDIATE COMPOUNDS FOR SYNTHESIS THEREOF | 2010 |
|
RU2444525C2 |
| METHOD FOR PRODUCTION OF NONAPEPTIDE ETHYL AMIDE | 1995 |
|
RU2086561C1 |
| PROCESS FOR PREPARING POLYPEPTIDES OR THEIR SALTS | 0 |
|
SU910116A3 |
| HEPTAPEPTIDE POSSESSING ABILITY OF INHIBITING MYOTROPIC EFFECT OF BRADIKININ | 0 |
|
SU1083560A1 |
| ENCEPHALIN ANALOGUE POSSESSING ANALGETIC EFFECT | 0 |
|
SU1048703A1 |
| METHOD OF SYNTHESIS OF DES-GLY-10,/D-LEY-6/-LH-RH-ETHYLAMIDE | 1994 |
|
RU2074191C1 |
| ANALOG OF ENKEPHALIN POSSESSING ANALGETIC ACTIVITY | 0 |
|
SU1116698A1 |
| ENCEPHALIN ANALOGUE POSSESSING PROLONGED ANALGETIC EFFECT | 0 |
|
SU1048705A1 |
| METHOD OF PRODUCING DECAPEPTIDES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | 0 |
|
SU1428205A3 |
| ANALOG OF ENKEPHALIN DISPLAYING ANALGETIC ACTIVITY | 0 |
|
SU1341970A1 |
