STABILISED ADHESIVE COMPOSITION CONTAINING DONEPEZIL Russian patent published in 2012 - IPC A61K9/70 A61K47/10 A61K47/20 A61P25/28 A61K31/445 A61K47/22 A61K47/26 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is an adhesive composition which decreases a number of donepezil related compounds formed in the donepezil-containing adhesive composition containing one, two or more types of combinations of the compounds selected from the following groups of the combinations of the compounds from (a) to (j) which are mixed in a layer of a donepezil-containing pressure sensitive glue: (a) isoascorbic acid or its metal salts and 2-mercaptobenzimidazole; (b) isoascorbic acid or its metal salts and 2,6-di-tert-butyl-4-methylphenol; (c) isoascorbic acid or its metal salts and metal salts of hydroxymethane sulphinic acid; (a) isoascorbic acid or its metal salts and rutin; (e) 2-mercaptobenzimidazole and 2,6-di-tert-butyl-4-methylphenol; (f) 2-mercaptobenzimidazole and metal salts of of hydroxymethane sulphinic acid; (g) 2-mercaptobenzimidazole and rutin; (h) 2,6-di-tert-butyl-4-methylphenol and metal salts of hydroxymethane sulphinic acid; (i) 2,6-di-tert-butyl-4-methylphenol and rutin; and (j) metal salts of hydroxymethane sulphinic acid and rutin.

EFFECT: adhesive composition is highly reliable and stable.

12 cl, 2 tbl