FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmacology, medicine, biochemistry and aims at creating a method for making a complex heparin preparation exhibiting anticoagulant-fibrinolytic action. The method for making the anticoagulant-fibrinolytic high-molecular heparin preparation consists in interaction of aqueous heparin and leucine mixed in molar ratio 1:3-4, the prepared product is frozen at temperature max. -10°C and lyophilised. Generally, the product is mixed for 25-30 min. Preferentially, 0.8-1.0% aqueous heparin and 0.3-1.0% leucine are used.
EFFECT: invention provides ease of implementation with making the oral preparation exhibiting no side proteolytic action and having storage stability.
4 cl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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|
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|
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|
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| METHOD OF PRODUCING COMPOSITIONS BASED ON HIGH-MOLECULAR HEPARIN WITH AMINO ACIDS AND 3-d METALS | 2015 |
|
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| PEPTIDE POSSESSING ANTICOAGULANT, FIBRIN-DEPOLYMERIZING, ANTI-THROMBOSIS AND FIBRINOLYTIC ACTIVITIES | 2005 |
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| PEPTIDE POSSESSING ANTI-COAGULANT, FIBRIN-DEPOLYMERIZATION, ANTI-THROMBOSIS AND FIBRINOLYTIC ACTIVITIES | 2005 |
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| AGENT POSSESSING ANTI-COAGULATING, ANTI-THROMBOCYTIC, ANTI-THROMBOSIS, FIBRIN-DEPOLYMERIZING AND FIBRINOLYTIC ACTIVITY | 2005 |
|
RU2290195C1 |
| ANTI-THROMBOSIS, ANTI-COAGULATING, FIBRIN-DEPOLYMERIZING AND FIBRINOLYTIC AGENT | 2005 |
|
RU2290194C1 |
