FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and pharmaceutical industry and discloses a pharmaceutical composition containing phenylephrine in a prolonged release dosage form, either alone, or in a combination with another active ingredient, such as an antihistamine, an analgesic, a febrifuge, a non-steroid anti-inflammatory drug or a mixture of two or more other active ingredients. In a preferential version of the invention, the composition contains a solid dosage form with hydroxypropyl methylcellulose and sodium-carboxymethyl cellulose as a prolonged release phenylephrine matrix. Phenylephrine is released from the solid dosage form during a long period of time, substantially irrespectively of pH.
EFFECT: development of the pharmaceutical composition containing phenylephrine in the prolonged release dosage form.
18 cl, 1 ex, 1 dwg
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