FIELD: medicine.
SUBSTANCE: subtype H1N1 influenza virus strain A/Russia/Ol/2009-ma is intended for study of the efficacy of therapeutic and preventive preparations for influenza virus in experiments in vitro and in vivo. The strain is deposited in the Collection of Cultures of the State Research Centre for Virology and Biotechnology "Vector" No.V-511. The strain is applied in determining definition influenza activity of the preparations in vitro with using MDCK cells. The strain provides a basis to create an adequate model for studying of activity of antiviral preparations for subtype H1N1 influenza virus in vivo consisting in intranasal infection of Balb/c mice of weight 14-16 g with the given strain.
EFFECT: strain is adapted for mice and is able to cause a lethal infection in mice that simplifies estimating the efficacy of influenza preparations.
3 dwg, 4 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| STRAIN OF INFLUENZA VIRUS OF SUBTYPE A/pochard/Siberia/249/08-MA H10N7 FOR OBTAINING ANTIGEN-CONTAINING DIAGNOSTIC PREPARATION AND DIAGNOSTIC POLYCLONAL SERUM, APPLICATION AS CONTROL REFERENCE-SAMPLE IN EVALUATING SPECIFICITY OF TEST SYSTEMS BASED ON PCR AND FOR STUDY OF ANTIVIRAL PREPARATIONS in vitro AND in vivo | 2013 |
|
RU2522813C1 |
| A/SWINE/SIBERIA/1SW/2016 SWINE INFLUENZA VIRUS STRAIN OF H1N1-SUBTYPE FOR INFLUENZA VIRUS DIAGNOSIS BY HIR AND PCR AND RESEARCH OF EFFECTIVENESS OF VACCINES AND ANTI-VIRAL DRUGS IN VITRO AND IN VIVO | 2016 |
|
RU2631938C1 |
| ADAPTED PANDEMIC INFLUENZA VIRUS STRAINS A/Tomsk/273/2010-MA1(H1N1pdm09), A/Tomsk/273/2010-MA2(H1N1pdm09) AND A/Tomsk/273/2010-MA3(H1N1pdm09) TO ASSESS THE EFFECT OF ANTIVIRAL DRUGS (VERSIONS) | 2015 |
|
RU2605317C1 |
| STRAIN OF INFLUENZA VIRUS A/COMMON MUSKRAT/CHANY LAKE/226/05 H2N2-SUBTYPE FOR USE IN DIAGNOSTICS OF INFLUENZA VIRUS BY METHODS OF RTGA AND PCR AND STUDYING EFFICACY OF ANTIVIRAL PREPARATIONS IN VITRO AND IN VIVO | 2015 |
|
RU2606030C1 |
| STRAIN OF INFLUENZA VIRUS A/BLACK-HEADED GULL/KAMCHATKA/123/2013 H11N8-SUBTITLE FOR USE IN INFLUENZA VIRUS DIAGNOSIS BY HIR AND PCR METHODS AND STUDY OF EFFECTIVENESS OF IN VITRO AND IN VIVO ANTI-VIRAL PREPARATIONS | 2016 |
|
RU2631932C1 |
| STRAIN A/Salekhard/01/2009(H1N1)v OF SUBTYPE H1N1 INFLUENZA A VIRUS FOR STUDYING THERAPEUTIC AND PROPHYLACTIC EFFICACY OF PREPARATIONS FOR INFLUENZA VIRUS | 2011 |
|
RU2457242C1 |
| STRAIN OF INFLUENZA VIRUS B/NOVOSIBIRSK/40/2017-MA FOR STUDYING THERAPEUTIC AND PREVENTIVE EFFICACY OF ANTIVIRAL PREPARATIONS IN VITRO AND IN VIVO | 2019 |
|
RU2703024C1 |
| METHOD FOR BODY PROTECTION AGAINST INFECTION CAUSED BY INFLUENZA A VIRUS SUBTYPE H1N1 STRAINS WITH PREPARATION OF HUMAN ALPHA-2 INTERFERON | 2013 |
|
RU2523554C1 |
| METHOD OF TREATING AVIAN INFLUENZA | 2012 |
|
RU2502512C2 |
| STRAIN OF FLU VIRUS A/IIV-Anadyr/177-ma/2009 (H1N1) pdm09, ADAPTED TO TISSUES OF LIGHT LABORATORY RODENTS | 2012 |
|
RU2487936C1 |
