STRAIN OF INFLUENZA VIRUS B/NOVOSIBIRSK/40/2017-MA FOR STUDYING THERAPEUTIC AND PREVENTIVE EFFICACY OF ANTIVIRAL PREPARATIONS IN VITRO AND IN VIVO Russian patent published in 2019 - IPC C12N7/00 

Abstract RU 2703024 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, medical virology and can be used in investigating the effectiveness of therapeutic and preventive preparations for influenza B virus. Strain of influenza virus B/Novosibirsk/40/2017-MA is intended for studying therapeutic and preventive efficacy of antiviral preparations in vitro and in vivo. Strain is produced on the basis of the original passportized antigenic parent strain of influenza virus B/Novosibirsk/40/2017 by blind passaging through the mice lungs and passage in the MDCK cell culture. Strain is deposited in the Collection of cultures of microorganisms of the State Research Center of Virology and Biotechnology "Vector" under registration number V-811.

EFFECT: strain is adapted to mice and is able to induce non-lethal influenza infection in mice, which enables to investigate therapeutic and preventive efficacy of antiviral preparations in vivo, as well as in vitro on MDCK cell culture.

1 cl, 4 dwg, 2 tbl, 4 ex

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RU 2 703 024 C1

Authors

Prokopeva Elena Aleksandrovna

Kurskaya Olga Grigorevna

Sobolev Ivan Andreevich

Sharshov Kirill Aleksandrovich

Murashkina Tatyana Aleksandrovna

Derko Anastasiya Aleksandrovna

Alekseev Aleksandr Yurevich

Shestopalov Aleksandr Mikhajlovich

Sysolyatin Sergej Viktorovich

Vorozhtsov Aleksandr Borisovich

Vaizova Olga Evgenevna

Sherstoboev Evgenij Yurevich

Dygaj Aleksandr Mikhajlovich

Dates

2019-10-15Published

2019-03-15Filed