METHOD OF ESTIMATING EFFECT OF ALPHA- AND BETA-ADRENOBLOCKER ON HEART RHYTHM STRUCTURE IN TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION Russian patent published in 2012 - IPC A61B5/00 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to cardiology. Before and after treatment course day ECG monitoring is carried out. Rythmogram of the entire period is divided into short segments for which average RRM value and RSPV are determined. Interval of RRM values change is divided into 8 ranges: (1)<0.573 s, (2) 0.573-0.648 s, (3) 0.649-0.724 s, (4) 0,725-0.800 s, (5) 0.801-0.873 s, (6) 0.874-0.948 s, (7) 0.949-1.024 s, (8)>1.024 s. Each short segment of rhythmogram is related to the group of the number of range which RRM value gets into. For each group with number I, number of n(i) of short segments of rhythmogram which got into it, and the average value RSPVM(i) of RSPV values of said segments. Total number N of short segments of rhythmogram on the studied time interval is calculated; number 10 is selected, for which n(1)+…+n(i0-1)<N/2, n(l)+…+n(i0-1)+n(i0)>N/2; numeration of ranges of heart rate changing is centred by number 10, giving to each range with number I number i-i0; comparing RSPV before and after treatment RSPVM(i) values are compared. Impact of adrenoblocker on the heart rhythm structure is estimated as positive, if most RSPV values for "centred" ranges with similar numbers increased, and reduction took place in not more than two "centred" ranges and for not more than 30 mc in each of them.

EFFECT: invention makes it possible to select anti-hypertensive therapy properly, estimate impact of arterial hypertension treatment with alpha- and beta-adrenoblocker in patients with arterial hypertension on the heart rhythm structure.

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